Recent Publications

Cellular Microbiology, 2020 (accepted). Shigella impairs human T lymphocyte responsiveness by hijacking actin cytoskeleton dynamics and TCR vesicular trafficking.  F. Samassa et al.

Cell, 2018;174(1):143-155. Intermittent pili-mediated forces fluidize Neisseria meningitidis aggregates promoting vascular colonization. D. Bonazzi, V. Lo Schiavo, S. Machata, I. Djafer-Cherif, P. Nivoit, V. Manriquez, H. Tanimoto, J. Husson, N. Henry, H. Chaté, R. Voituriez, and G. Duménil.

Molecular Biology of the Cell, 2017; 28(23): 3229-3239. Micropipette Force Probe to quantify single-cell force generation: application to T cell activation. A. Sawicka, A. Babataheri, S. Dogniaux, A. I. Barakat, D. Gonzalez-Rodriguez, C. Hivroz, and J. Husson.

Cell, 2016;165(1):100-110. Basu R*, Whitlock BM*, Husson J*, Le Floc’h A, Jin W, Dotiwala F, Giannone G, Hivroz C, Lieberman J, Kam LC, and Huse M. (* co-first authors). Cytotoxic T cells use mechanical force to potentiate target cell killing.

Molecular Biology of the Cell 2016; 27(22): 3574-3582. Guillou L, Babataheri A, Saitakis M, Bohineust A, Dogniaux S, Hivroz C, Barakat AI, and Husson J. T lymphocyte passive deformation is controlled by unfolding of membrane surface reservoirs (journal cover, see below).

Our research focuses on the mechanics of biological systems at the cellular, intracellular, and molecular level. We develop new techniques, mainly based on micropipettes coupled to microscopy. We also like to artistically illustrate cellular processes.

Keywords: Atherosclerosis, Cancer, Cell Mechanics,  Endothelial Cells, Force Generation, Immunological Synapse,  Leukocytes, Membranes, Microindentation, Micropipettes, Microscopy, Microtubules,  Mitochondria, Rigidity Sensing, T lymphocytes, Transendothelial Migration.