Our research focuses on the mechanics of biological systems at the cellular, intracellular, and molecular level. We develop new techniques, mainly based on micropipettes coupled to microscopy. We also like to artistically illustrate cellular processes.

Recent Publications

Biophysical Journal, 2022; 121 (8):1381-1394. Distinct timing of neutrophil spreading and stiffening during phagocytosis. A. Zak, S. Dupré-Crochet, E. Hudik, A.I. Barakat, O. Nüsse, J. Husson.


Biophysical Journal, 2021; 120(9): 1692-1704. Rapid viscoelastic changes are a hallmark of early leukocyte activation. Alexandra Zak, Sara Violeta Merino-Cortés, Anaïs Sadoun, Farah Mustapha, Avin Babataheri, Stéphanie Dogniaux, Sophie Dupré-Crochet, Elodie Hudik, Hai-Tao He, Abdul I. Barakat, Yolanda R. Carrasco, Yannick Hamon, Pierre-Henri Puech, Claire Hivroz, Oliver Nüsse, Julien Husson.

Biology of the Cell, 20 January 2021; https://doi.org/10.1111/boc.202000133. Influence of external forces on actin-dependent T cell protrusions during immune synapse formation. Andrés Ernesto Zucchetti, Noémie Paillon, Olga Markova, Stéphanie Dogniaux, Claire Hivroz, and Julien Husson.

Science Signaling, 2020; 13(627), eaaw8214. Diacylglycerol kinase z regulates actin cytoskeleton remodeling and mechanical forces at the B cell immune synapse. Sara V. Merino-Cortes, Sofia R. Gardeta, Sara Roman-Garcia, Ana Martínez-Riaño, Judith Pineau, Rosa Liebana, Isabel Merida, Ana-Maria Lennon Dumenil, Paolo Pierobon, Julien Husson, Balbino Alarcon, and Yolanda R. Carrasco.


Cellular Microbiology, 2020; e13166. Shigella impairs human T lymphocyte responsiveness by hijacking actin cytoskeleton dynamics and TCR vesicular trafficking.  Fatoumata Samassa, Mariana L. Ferrari, Julien Husson, Anastassia Mikhailova, Ziv Porat, Florence Sidaner, Katja Brunner, Teck-Hui Teo, Elisabetta Frigimelica, Jean-Yves Tinevez, Philippe J. Sansonetti, MariaIsabel Thoulouze, Armelle Phalipon.